Search results for "Dengue fever"

An epigenetic ‘extreme makeover’: the methylation of flaviviral RNA (and beyond)

2020

Beyond their high clinical relevance worldwide, flaviviruses (comprising dengue and Zika viruses) are of particular interest to understand the spatiotemporal control of RNA metabolism. Indeed, their positive single-stranded viral RNA genome (vRNA) undergoes in the cytoplasm replication, translation and encapsidation, three steps of the flavivirus life cycle that are coordinated through a fine-tuned equilibrium. Over the last years, RNA methylation has emerged as a powerful mechanism to regulate messenger RNA metabolism at the posttranscriptional level. Not surprisingly, flaviviruses exploit RNA epigenetic strategies to control crucial steps of their replication cycle as well as to evade sen…

Anti-herpetic and anti-dengue activity of abietane ferruginol analogues synthesized from (+)-dehydroabietylamine

2015

The abietane-type diterpenoid (+)-ferruginol (1), a bioactive compound isolated from several plants, has attracted much attention as consequence of its pharmacological properties, which includes antibacterial, antifungal, antimicrobial, cardioprotective, anti-oxidative, anti-plasmodial, leishmanicidal, anti-ulcerogenic, anti-inflammatory and antitumor actions. In this study, we report on the antiviral evaluation of ferruginol (1) and several analogues synthesized from commercial (+)-dehydroabietylamine. Thus, the activity against Human Herpesvirus type 1, Human Herpesvirus type 2 and Dengue Virus type 2, was studied. Two ferruginol analogues showed high antiviral selectivity index and reduc…

2020

Vector-borne diseases such as malaria, dengue fever, West Nile virus, and so forth are some of the most prominent threats to human health. They are transmitted to the human population by infected insects or by direct transmission between humans. The epidemic process relies on suitable environmental and climatic conditions. Indeed, climatic factors affect the development of pathogens in vectors as well as the population dynamics of the vectors impacting significantly the incidence of disease in the human population. While the influence of the climatic conditions on Vector-borne diseases is well-documented, there is a strong need to design more realistic epidemiological models incorporating e…

Multiple Linear Regression to predict larvicidal activity against <em>Aedes aegypti </em>mosquito

2017

Vector-borne diseases are one of the important health problems in most tropical countries. Aedes aegypti is an important vector for transmission of dengue, yellow fever, chikungunya, arthritis, and Zika fever. According to the World Health Organization, it is estimated that Ae. aegypti causes 50 million infections and 25,000 deaths per year. The emerging scenario highlights that the eco-friendly and effective control measures for mosquito vectors is of crucial importance. One of the most effective vector control measures has been the use of larvicidal compounds however; this success was short lived due to development of resistance against them in many mosquito strains, ecological imbalance …

El TRATAMIENTO PERIODÍSTICO DE LAS NOTICIAS RELACIONADAS CON LOS VIRUS DEL DENGUE Y ZIKA EN LOS MEDIOS DIGITALES DE HONDURAS (2010-2017)

2019

Resumen: En 1979, se identificó la primera epidemia de dengue en Honduras. En 2010, las autoridades sanitarias y gubernamentales hondureñas decretaron lo que sería la quinta epidemia que afectaba a la población. Cinco años más tarde, una enfermedad emergente llegó al continente americano: el zika. Las entidades internacionales como la Organización Mundial de la Salud y la Organización Panamericana de Salud extendieron la alerta a nivel latinoamericano, en especial a los países propensos por su situación geográfica, climatológica y situación socioeconómica. El objetivo del presente estudio es analizar el contenido de las noticias que se publicaron sobre los virus del dengue y zika en tres di…

Joint Estimation of Relative Risk for Dengue and Zika Infections, Colombia, 2015–2016

2019

We jointly estimated relative risk for dengue and Zika virus disease (Zika) in Colombia, establishing the spatial association between them at the department and city levels for October 2015–December 2016. Cases of dengue and Zika were allocated to the 87 municipalities of 1 department and the 293 census sections of 1 city in Colombia. We fitted 8 hierarchical Bayesian Poisson joint models of relative risk for dengue and Zika, including area- and disease-specific random effects accounting for several spatial patterns of disease risk (clustered or uncorrelated heterogeneity) within and between both diseases. Most of the dengue and Zika high-risk municipalities varied in their risk distributio…

Spatio-Temporal Modeling of Zika and Dengue Infections within Colombia

2018

The aim of this study is to estimate the parallel relative risk of Zika virus disease (ZVD) and dengue using spatio-temporal interaction effects models for one department and one city of Colombia during the 2015&ndash

Predicting dengue fever outbreaks in French Guiana using climate indicators

2016

Background Dengue fever epidemic dynamics are driven by complex interactions between hosts, vectors and viruses. Associations between climate and dengue have been studied around the world, but the results have shown that the impact of the climate can vary widely from one study site to another. In French Guiana, climate-based models are not available to assist in developing an early warning system. This study aims to evaluate the potential of using oceanic and atmospheric conditions to help predict dengue fever outbreaks in French Guiana. Methodology/Principal Findings Lagged correlations and composite analyses were performed to identify the climatic conditions that characterized a typical e…

Vascular Leakage in Severe Dengue Virus Infections: A Potential Role for the Nonstructural Viral Protein NS1 and Complement

2006

Background Vascular leakage and shock are the major causes of death in patients with dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Thirty years ago, complement activation was proposed to be a key underlying event, but the cause of complement activation has remained unknown. Methods The major nonstructural dengue virus (DV) protein NS1 was tested for its capacity to activate human complement in its membrane-associated and soluble forms. Plasma samples from 163 patients with DV infection and from 19 patients with other febrile illnesses were prospectively analyzed for viral load and for levels of NS1 and complement-activation products. Blood and pleural fluids from 9 patient…

Two-level resolution of relative risk of dengue disease in a hyperendemic city of Colombia.

2018

Risk maps of dengue disease offer to the public health officers a tool to model disease risk in space and time. We analyzed the geographical distribution of relative incidence risk of dengue disease in a high incidence city from Colombia, and its evolution in time during the period January 2009—December 2015, identifying regional effects at different levels of spatial aggregations. Cases of dengue disease were geocoded and spatially allocated to census sectors, and temporally aggregated by epidemiological periods. The census sectors are nested in administrative divisions defined as communes, configuring two levels of spatial aggregation for the dengue cases. Spatio-temporal models including…